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STATINS THE BOTTOM LINE

June 17, 2012

STATINS THE BOTTOM LINE

I like to provide this information to people when they ask if  Mom or Dad or oneself should be prescribed a statin. My sister just returned from her pediatrician’s office and he suggested they check a serum cholesterol on her daughter who is 9 years old. Yes, that’s right. It appears that the statin industry has already seeped, like a sewage lagoon into a ground-water table, into a new market the kid market. Just when you thought it was safe to go back into the water. I do not know how familiar you are with the side effects of statins but try to imagine robbing a 9 year old of CoQ10 and cholesterol for a lifetime! Statins have been around since the mid-1990’s. In a couple years we will hit the 20 year mark and for some that will be the time they have been on a statin. All I can say is that poor bastard. That’s if they make it that long. What might they look like? So far we see brain impairment, massive increases in polyneuropathy, amnesia, weakness, fatigue, sore muscles, aches and pains, impotence, low stress hormones, inability to manufacture Vit D3. Oh but that’s not an issue right because we all know that sunbathing for even 5 minutes shows a clear and consistent linear association with increased skin cancer. OMG! Run. Where’s the slather I need an SPF of at least 100. (Don’t get me started on Vit D 3 and sunlight and tans because I will really get pissed-I love the sun-next blog)

Don’t forget the exponential rise in heart failure over the last decade-CoQ10 related? Could very well be it has not been ruled out.

In summary what can we say about statins so far? (from my upcoming book)

Overall they provide modest protection to women and men, about 20%, against heart attack and overall mortality only in those who already have heart disease (that’s called secondary prevention).

In contradistinction a Jan 17, 2008 Business Week article states-statins have never been shown to benefit women of any age.

As far as primary prevention goes-and this is where the vast majority of prescriptions are sold-the data do not support their use.

Dr Abramson published an article in the Lancet in 2007. Our analysis suggests that lipid-lowering statins should not be prescribed for true primary prevention in women of any age or for men older than 69 years. High-risk men aged 30-69 years should be advised that about 50 patients need to be treated for 5 years to prevent one event. In our experience, many men presented with this evidence do not choose to take a statin, especially when informed of the potential benefits of lifestyle modification on cardiovascular risk and overall health. This approach, based on the best available evidence in the appropriate population, would lead to statins being used by a much smaller proportion of the overall population than recommended by any of the guidelines.[1]

In another study published in the Archives of Internal Medicine in 2010 a group of researchers set out to find if statins should be prescribed for patients without CVD or previous heart attack but are considered high risk for such events. In other words are statins indicated for primary prevention? They looked at over 65,000 patients in a Meta-analysis of 11 studies.

Conclusion This literature-based meta-analysis did not find evidence for the benefit of statin therapy on all-cause mortality in a high-risk primary prevention set-up.[2]


[2]   Statins and All-Cause Mortality in High-Risk Primary Prevention A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants Kausik K. Ray, MD, MPhil, FACC, FESC; Arch Intern Med. 2010;170(12):1024-1031.                                                                 

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