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Statins and CoQ10 depletion

June 4, 2012

This is a (very) Imagesmall piece of my upcoming book. I am going to periodically add in pieces of my work as I go along. Any comments on references or additions would be helpful.

CoQ 10 depletion
There’s a reason why the other name for CoQ 10 is ubiquinone as in ubiquitous because it’s everywhere in your body er, well, it’s supposed to be unless you are on a statin. Now imagine what that’s like depleting a vital molecule everywhere in your body for the rest of your life! CoQ 10 is critically needed in what is called cellular aerobic respiration which is the main way we use energy. In fact 95% of the body’s energy (ATP) is generated this way.  CoQ 10 is so vital that there is no other molecule that can perform its duties of transferring electrons from complex Icomplex IIcomplex III in the electron transport chain (ETC) within the mitochondria. If we lost this ability we could not utilize oxygen to live. Cyanide owes its lethality to this very property. The organs most dependent on large quantities of CoQ 10 and hence aerobic energy are the heart, liver and kidneys.

Finally CoQ 10 is a potent antioxidant in many cellular systems it is also located within the LDL cholesterol molecule, where it functions to keep LDL from being oxidized.

The second fundamental property of CoQlo involves its antioxidant (free radical scavenging) fimctions (Beyer 1990, Villalba 1997). CoQlo is the only known naturally occurring lipid soluble antioxidant for which the body has enzyme systems capable of regenerating the active reduced ubiquinol form (Ernster 1993) It is also known that CoQ10 levels steadily fall after the age of 40 (Kalen 1989,
Soderberg 1990). .

Need I say more to impress upon you how important it is to maintain adequate levels of CoQ 10? Statins critically reduce the levels of this important molecule and those who are on statins are all part of a massive experiment. What happens when you keep reducing a patient’s CoQ 10 levels for decades? We do not know for sure but a massive rise in congestive heart failure in the last decade may be due at least in part to this.  As a precaution which is backed up by dozens of studies Peter H. Langsjoen, M.D., author of the quote above, suggests that we supplement with 100-200 mg of CoQ 10 per day if on a statin. He also suggested due to overwhelming evidence that the FDA provide a Black Box warning  for all patients that emphasizes the dangers and importance of supplementation with CoQ 10 if you are on a statin.

Impotence and Low Testosterone levels
Information from all of these sources identified fibrates as a source of ED. A substantial number of cases of ED associated with statin usage have been reported to regulatory agencies. Case reports and clinical trial evidence supported the suggestion that statins can also cause ED.
In a new study out of Italy researchers found a correlation with statins and ED: April 16, 2010 — Statin therapy prescribed to lower cholesterol also appears to lower testosterone, according to a new study that evaluated nearly 3,500 men who had erectile dysfunction or ED.
”Current statin therapy is associated with a twofold increased prevalence of hypogonadism,” a condition in which men don’t produce enough testosterone, study author Giovanni Corona, MD, PHD, a researcher at the University of Florence in Italy.
Researchers appear to be stymied by the mechanism suggesting that there is either a correlation between low testosterone (T) and high LDL or the fact that statins can decrease the production of testosterone by critically decreasing the building blocks namely cholesterol. How about both? We often see an increase in serum lipids as a persons T falls in the same way that we see it with hypothyroidism which the study should have checked for as well. Likewise it has been shown that statins can reduce critical hormone levels of both the sex and stress variety.

Statins can apparently interfere with orgasms as well: In “Statins Reduce Orgasm: Results from the UCSD Statins Study” Dr. Beatrice Golomb and colleagues from the University of California-San Diego reported today on their study of 1,067 men and women without heart disease with a LDL cholesterol of 119-190 mg/dL. Overall statins had a negative effect on orgasms, which was statistically significant only for men, and only for Zocor. Dr Golomb was quoted as saying that “it takes a lot of energy to orgasm,” implying that CoQ 10 depletion may be involved.

sorry but my footnote numbers disappeared after copy and paste…..

(https://en.wikipedia.org/wiki/Coenzyme_Q10) 06/03/2012
(http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-02-Exhibit_A-vol1.pdf) 06/04/2012
(http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-02-Exhibit_A-vol1.pdf) 09/04/2012
Rizvi K, Hampson JP and Harvey JN. Do lipid-lowering drugs cause erectile dysfunction? A systematic review. Family Practice 2002; 19: 95–98.
(http://www.webmd.com/erectile-dysfunction/news/20100416/statins_may_lower_testosterone_libido) 06/04/2012
(http://www.beforeyoutakethatpill.com/index.php/2009/03/06/statins-interfere-with-orgasms-live-update-from-aps-in-chicago/) 06/04/2012

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